“American Weeds and Useful Plants: Being a Second and Illustrated Edition of Agricultural Botany” by William Darlington is a comprehensive botanical reference first published in 1859 and later revised in 1865. The work serves as an extensive guide to the flora of the United States, focusing on plants that are significant to agriculture, whether as weeds or as beneficial species. Darlington, a physician and botanist, collaborated with George Thurber to produce this edition, which includes detailed descriptions and illustrations of various plants.​

The book categorizes plants based on their utility and impact on agriculture. It provides insights into the characteristics, growth habits, and potential uses of numerous species, emphasizing those that require attention from American agriculturists. The inclusion of illustrations enhances the reader’s understanding and identification of the plants discussed. This edition is particularly valuable for its historical perspective, reflecting the botanical knowledge and agricultural concerns of the mid-19th century.​

Darlington’s work remains a significant contribution to the field of economic botany. Its detailed accounts of both weeds and useful plants offer timeless insights into the relationship between flora and agriculture. The book’s enduring relevance underscores the importance of understanding plant life in the context of agricultural practices.