The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals is a comprehensive reference work that has served as an authoritative source of information on chemical compounds for over a century. First published in 1889 by the German chemical company Emanuel Merck, it has evolved into a vital resource for scientists, healthcare professionals, and researchers worldwide. The 15th edition, released in 2013 by the Royal Society of Chemistry, continues this tradition with significant updates and enhancements.
This edition includes over 10,000 monographs detailing more than 18,000 chemical substances, encompassing human and veterinary drugs, biologics, natural products, and industrial chemicals. Each entry provides essential data such as chemical names, CAS Registry Numbers, molecular formulas, molecular weights, structural formulas, physical properties, toxicity information, and references to scientific literature. Notably, over 500 new monographs have been added, and more than 3,500 existing entries have been updated to reflect the latest scientific standards. Molecular weights have been recalculated using the latest IUPAC standards, and periodic table and atomic weight tables have been revised accordingly.
The Merck Index is organized to facilitate efficient information retrieval. It includes several cross-references, such as name indexes, CAS Registry Numbers, chemical formulas, and therapeutic categories. Additionally, the 15th edition features enhanced supplemental tables covering topics like vaccines, medicinal radioisotopes, and conversion factors. A significant addition is the inclusion of over 500 named organic reactions, expanding the resource’s utility for researchers and educators in the field of chemistry.
For users seeking digital access, a one-year complimentary subscription to The Merck Index Online is included with the purchase of the print edition. The online platform offers a fully searchable database of over 11,500 monographs, including historic entries not available in the print edition. This digital resource supports advanced search functionalities, such as structure searching and data element queries, enhancing its value for professionals and students alike.
The Merck Index remains an indispensable tool for anyone involved in the study or application of chemical substances. Its rigorous compilation of data, coupled with continuous updates, ensures its position as a cornerstone in scientific reference literature. Whether in print or online, it continues to support the advancement of knowledge across various disciplines, including chemistry, pharmacology, and environmental science.