Materia Medica Pura by Samuel Hahnemann is a foundational text in homeopathic medicine, first published in 1811. The first volume, released in 1811, presents the pathogenesis of 12 medicines, six of which were new to homeopathic literature. This work marked a significant departure from traditional medical practices by focusing on the effects of substances on healthy individuals rather than relying on speculative theories or chemical analyses.​

Hahnemann’s approach to proving remedies involved administering substances to healthy volunteers and meticulously recording their symptoms. This empirical method aimed to uncover the true therapeutic potential of medicines, emphasizing the importance of understanding the dynamic effects of substances on the human body. The first volume includes detailed accounts of the symptoms produced by twelve substances, providing a comprehensive overview of their potential therapeutic applications.​

The structure of each remedy’s description in Materia Medica Pura follows a systematic format. It begins with the name of the drug, followed by information on its preparation, parts used, properties, and potential toxic effects. The symptoms are then listed in a specific order, starting from general sensations and progressing to more localized effects. Each symptom is numbered and accompanied by the time of occurrence after administration, offering a detailed timeline of the substance’s action.​

The first volume of Materia Medica Pura lays the groundwork for homeopathic practice by providing a detailed and systematic account of the effects of twelve substances on healthy individuals. Hahnemann’s empirical approach challenges traditional medical theories and underscores the importance of understanding the dynamic interactions between medicines and the human body. This volume serves as a critical resource for homeopathic practitioners, offering insights into the therapeutic potential of various substances based on their proven effects.​