Samuel Cooper’s 1797 work, “A Dissertation on the Properties and Effects of the Datura Stramonium,” provides a comprehensive examination of the Datura stramonium plant, known for its potent medicinal and toxic properties. Cooper delves into the plant’s historical uses, pharmacological effects, and the balance between its therapeutic benefits and potential dangers.​

Cooper begins by exploring the historical context of Datura stramonium, highlighting its use in traditional medicine across various cultures. He notes that the plant has been employed to treat ailments such as asthma, muscle spasms, and pain. The author emphasizes the importance of understanding the plant’s properties to harness its medicinal potential effectively.​

The dissertation then examines the pharmacological aspects of Datura stramonium, focusing on its active compounds, including atropine, hyoscyamine, and scopolamine. Cooper discusses how these alkaloids interact with the human body, particularly their anticholinergic effects, which can lead to both therapeutic outcomes and toxic reactions. He underscores the necessity of precise dosing and administration to mitigate risks associated with the plant’s potent compounds.​

In conclusion, Cooper’s work serves as a valuable resource for understanding Datura stramonium’s dual nature as both a medicinal remedy and a potential toxin. He advocates for continued research and cautious application of the plant in medical practices, emphasizing the need for informed usage to maximize benefits while minimizing harm.