​Charles A. Lee’s 1848 publication, A Catalogue of the Medicinal Plants, Indigenous and Exotic, Growing in the State of New-York, stands as a testament to the rich botanical heritage of New York State. In this work, Lee meticulously documents over 1,450 flowering plant species, including approximately 150 recognized for their medicinal properties. The catalogue not only lists these plants but also provides insights into their chemical compositions and therapeutic applications, reflecting the medical understanding of the mid-19th century. Lee’s endeavor underscores the significance of both native and naturalized species, many of which were introduced through agricultural practices, highlighting their roles in traditional medicine and their potential in contemporary therapeutic contexts.​

The book delves into various plant categories, from herbaceous and woody plants to ferns, mosses, liverworts, lichens, and seaweeds. Lee emphasizes the underexplored medicinal potential of these groups, particularly fungi, which he notes comprise an estimated 3,000 species in the state. His observations call attention to the vast opportunities for research and discovery within New York’s diverse ecosystems. By advocating for a deeper investigation into these lesser-known species, Lee champions a forward-thinking approach to botanical science, encouraging future scholars to build upon the foundational knowledge he presents.​

Organized by natural order, the catalogue serves as both a practical reference for medical professionals and a scholarly resource for botanists. Lee’s systematic classification facilitates an understanding of the relationships between plant families and their medicinal uses, fostering a holistic view of plant-based remedies. This structured approach not only aids in the identification and application of medicinal plants but also reflects the scientific rigor of the period. By bridging the gap between traditional knowledge and scientific inquiry, Lee’s work exemplifies the integration of empirical observation with established medical practices.​

Lee’s catalogue is more than a mere listing of plants; it is a comprehensive exploration of the interplay between nature and medicine. His dedication to documenting the medicinal flora of New York provides invaluable insights into the state’s botanical diversity and its historical applications in healthcare. This work not only preserves traditional medicinal knowledge but also lays the groundwork for future research and innovation in the field of botanical medicine. By honoring the past and looking toward the future, Lee’s publication remains a significant contribution to the understanding of medicinal plants and their enduring relevance in both historical and modern contexts.